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The pooled odds ratios were 1.48 (95% CI: 1.361.61) for current users, 1.84 (95% CI: 1.512.23) for former users, and 1.79 (95% CI: 1.422.25) for ever users

So this concept of moving down the continuum should only apply to adult cigarette smokers

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In contrast to combustible cigarettes, all the bio-markers were significantly reduced in the blood and urine of smokers who switched to any of the NSPS flavours, and the mean percent reduction was similar to the percent reduction seen in the abstinence arm, says the study

Adjusted OR, adjusted Odds Ratio